1、evocatal GmbH 更名為 evoxx
2016年10月：德國(guó)海姆的一家生物催化公司evocatal更名為evoxx技術(shù)。這次更名是在evocatal和碳水化合物專家aevotis完成合并之后（似乎他們對(duì)首字母大寫并不是特別感冒）。
2、Codexis完成了對(duì)默克的CodeEvolver?技術(shù)交付
2016年10月5日：Codexis宣布完成專有CodeEvolver?蛋白質(zhì)工程平臺(tái)技術(shù)向默克轉(zhuǎn)移的第二個(gè)也是最后一個(gè)階段，簽署了一份排他性的許可協(xié)議。Codexis在2016年第四季度將會(huì)收到默克的800萬(wàn)美元的里程碑支付。
3、Zymergen融資1.3億美元
2016年10月11日，合成生物和通路工程科技公司Zymergen日前宣布獲得1.3億美元由軟銀牽頭的B輪融資。該公司從2013年成立至今已經(jīng)完成了超過(guò)2億美元的增長(zhǎng)。
4、諾維信推出首個(gè)生物泡沫控制劑
2016年11月8號(hào)，世界領(lǐng)先的工業(yè)酶公司諾維信宣布推出一種名為FermaxTM新的蛋白酶產(chǎn)品，這種蛋白酶能夠減少發(fā)酵過(guò)程中泡沫的產(chǎn)生，如從甘蔗乙醇的發(fā)酵過(guò)程。更多此蛋白酶的信息見(jiàn)下面的酶介紹。
5、Codexis宣布與Tate & Lyle簽訂酶供應(yīng)協(xié)議
2016年12月6日，Codexis宣布與Tate & Lyle簽訂一份排他性協(xié)議，作為Tate & Lyle的食品原料生產(chǎn)中使用專有酶的全球材料和解決方案的提供者。
會(huì)議預(yù)告
1）2017年1月9日-10日，生物催化與生物化學(xué)：生物催化遇上合成生物學(xué)，美國(guó) 圣地亞哥；
http://www.chi-peptalk.com/biocatalysts-conference/
2）2017年3月6日-8日，有機(jī)過(guò)程的研究和開(kāi)發(fā)，帕薩迪納，美國(guó)；
https://scientificupdate.co.uk/index.php/conferences/conferences-and-workshops/details/297-Organic-Process-Research-and-Development-Europe.html
最新發(fā)表文獻(xiàn)摘選：
1）Fusion of agarase and neoagarobiose hydrolase for mono-sugar production from agar. Alkotaini B, Han NS, Kim BS. Appl Microbiol Biotechnol. 2016 Nov 25.
https://www.ncbi.nlm.nih.gov/pubmed/27888333
2）Chemoenzymatic Synthesis of trans-β-Aryl-δ-hydroxy-γ-lactones and Enzymatic Kinetic Resolution of Their Racemic Mixtures. Skrobiszewski A, Gladkowski W, Maciejewska G, Wawrzeńczyk C. Molecules. 2016 Nov 23;21(11). pii: E1552.
https://www.ncbi.nlm.nih.gov/pubmed/27886108
3）Sequential Enzymatic Conversion of α-Angelica Lactone to γ-Valerolactone through Hydride-Independent C=C Bond Isomerization. Turrini NG, Eger E, Reiter TC, Faber K, Hall M. ChemSusChem. 2016 Nov 25. doi:10.1002/cssc.201601363.
https://www.ncbi.nlm.nih.gov/pubmed/27885835
4）Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools. Chang CA, Huang YM, Mueller LJ, You W. Catalysts. 2016 Jun;6(6). pii: 82. https://www.ncbi.nlm.nih.gov/pubmed/27885336
5）Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life. Kan SB, Lewis RD, Chen K, Arnold FH. Science. 2016 Nov 25;354(6315):1048-1051.
https://www.ncbi.nlm.nih.gov/pubmed/27885032
6）The Oxidosqualene Cyclase from the Oomycete Saprolegnia parasitica Synthesizes Lanosterol as a Single Product. Dahlin P, Srivastava V, Bulone V, McKee LS. Front Microbiol. 2016 Nov 9;7:1802.
https://www.ncbi.nlm.nih.gov/pubmed/27881978
7）Membrane bioreactors for pharmaceutical applications: optically pure
enantiomers production. Piacentini E, Mazzei R, Giorno L. Curr Pharm Des. 2016 Nov 23.https://www.ncbi.nlm.nih.gov/pubmed/27881063
8）Stimulation of Laccase Biocatalysis in Ionic Liquids: A Review on Recent Progress.
https://www.ncbi.nlm.nih.gov/pubmed/27875965
9）Laccase catalysis for the synthesis of bioactive compounds. Kudanga T, Nemadziva B, Le Roes-Hill M. Appl Microbiol Biotechnol. 2016 Nov 21.Review.
https://www.ncbi.nlm.nih.gov/pubmed/27872999
10）Protein-based inverse opals: A novel support for enzyme immobilization. >Jiang Y, Sun W, Wang Y, Wang L, Zhou L, Gao J, He Y, Ma L, Zhang X. Enzyme Microb Technol. 2017 Jan;96:42-46. doi: 10.1016/j.enzmictec.2016.08.021.
https://www.ncbi.nlm.nih.gov/pubmed/27871384
11）Aroma Release in Wine Using Co-Immobilized Enzyme Aggregates. 2016 Nov 8;21(11). pii: E1485.https://www.ncbi.nlm.nih.gov/pubmed/27834828
12）Identification and characterization of a thermostable and cobalt-dependent amidase from Burkholderia phytofirmans ZJB-15079 for efficient synthesis of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid. Wu ZM, Zheng RC, Tang XL, Zheng YG. Appl Microbiol Biotechnol. 2016 Nov 10.
https://www.ncbi.nlm.nih.gov/pubmed/27832306
13）Structure and function of an ancestral-type β-decarboxylating dehydrogenase from Thermococcus kodakarensis. Shimizu T, Yin L, Yoshida A, Yokooji Y, Hachisuka SI, Sato T, Tomita T, Nishida H, Atomi H, Kuzuyama T, Nishiyama M. Biochem J. 2016 Nov 9. pii: BCJ20160699.
https://www.ncbi.nlm.nih.gov/pubmed/27831491
14）Engineering Styrene Monooxygenase for Biocatalysis: Reductase-Epoxidase Fusion Proteins. Heine T, Tucker K, Okonkwo N, Assefa B, Conrad C, Scholtissek A, Schlomann M, Gassner G, Tischler D. Appl Biochem Biotechnol. 2016 Nov 9.
https://www.ncbi.nlm.nih.gov/pubmed/27830466
15）High adaptability of the omega loop underlies the substrate-spectrum-extension
evolution of a class A β-lactamase, PenL. Yi H, Choi JM, Hwang J, Prati F, Cao TP, Lee SH, Kim HS. Sci Rep. 2016 Nov 9;6:36527. doi: 10.1038/srep36527.
https://www.ncbi.nlm.nih.gov/pubmed/27827433
16）Crystal structure of fuculose aldolase from the Antarctic psychrophilic yeast Glaciozyma antarctica PI12. Jaafar NR, Littler D, Beddoe T, Rossjohn J, Illias RM, Mahadi NM, Mackeen MM, Murad AM, Abu Bakar FD. Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt11):831-839. https://www.ncbi.nlm.nih.gov/pubmed/27827354
17）Improving the catalytic efficiency of Bacillus pumilus CotA-laccase by site-directed mutagenesis. Chen Y, Luo Q, Zhou W, Xie Z, Cai YJ, Liao XR, Guan ZB. Appl Microbiol Biotechnol. 2016 Nov 8.https://www.ncbi.nlm.nih.gov/pubmed/27826721
18）Enhancement of catalytic, reusability, and long-term stability features of Trametes versicolor IBL-04 laccase immobilized on different polymers. Asgher M, Noreen S, Bilal M. Int J Biol Macromol. 2016 Nov 5;95:54-62. doi: 10.1016/j.ijbiomac.2016.11.012.
https://www.ncbi.nlm.nih.gov/pubmed/27825994
19）Trypsin-catalyzed multicomponent reaction: A novel and efficient one-pot synthesis of thiazole-2-imine derivatives. Zhou J, Huang X, Zhang Z, Song P, Li Y. J Biotechnol. 2016 Nov 5;241:14-21. doi:
10.1016/j.jbiotec.2016.11.004.
https://www.ncbi.nlm.nih.gov/pubmed/27825826
20）Solvent effect on hydrogen bonded Tyr…Asp…Arg triads: Enzymatic catalyzed model system. Yan S, Yao L, Kang B, Lee JY. Comput Biol Chem. 2016 Dec;65:140-147. doi: 10.1016/j.compbiolchem.2016.10.013.
https://www.ncbi.nlm.nih.gov/pubmed/27825065
21）Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Biocatalysis , Hydroxylation Reactions. Pelosi L, Ducluzeau AL, Loiseau L, Barras F, Schneider D, Junier I, Pierrel F. mSystems. 2016 Aug 30;1(4). pii: e00091-16.
https://www.ncbi.nlm.nih.gov/pubmed/27822549
22）Identification of a new plasmid-encoded cytochrome P450 CYP107DY1 from Bacillus megaterium with a catalytic activity towards mevastatin. Milhim M, Putkaradze N, Abdulmughni A, Kern F, Hartz P, Bernhardt R. J Biotechnol. 2016 Dec 20;240:68-75. doi: 10.1016/j.jbiotec.2016.11.002.
https://www.ncbi.nlm.nih.gov/pubmed/27816653
23）Rotating packed bed reactor for enzymatic synthesis of biodiesel. Xu J, Liu C, Wang M, Shao L, Deng L, Nie K, Wang F. Bioresour Technol. 2016 Oct 18. pii: S0960-8524(16)31451-1. doi: 10.1016/j.biortech.2016.10.045.
https://www.ncbi.nlm.nih.gov/pubmed/27816349
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